Zimmermann T, Höchel J, Becka M, Boettger MK, Rohde B, Schug B, Kunert KS, Donath F

Topical administration of regorafenib eye drops: phase I dose-escalation study in healthy volunteers

British Journal of Clinical Pharmacology (2018)


Regorafenib: first in human as eye drops

We tested regorafenib eye drops in healthy subjects to assess ophthalmic tolerability, safety and systemic exposure. This is the first time regorafenib was administered to the eye. For details see the recently published paper in British Journal of Clinical Pharmacology.

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