Magnetic Marker Monitoring (MMM) is a technique for visualising the transit of a solid oral dosage form through the gastrointestinal tract. Disintegration and drug-release characteristics can also be determined. A precise 3-dimensional localisation with high specific resolution (few millimetres’ precision) can be achieved. The method is based on incorporating small amounts of magnetite (about 1 mg of black iron oxide, E172) into the formulation and subsequent magnetic flux density measurements.
The marker substance magnetite is suitable for IMPDs in the European Union!
The technique allows different applications during formulation development and also for regulatory purposes:
Our measurement system is currently being changed. We expect to have the new measurement chamber running by autumn this year.
For further details download our MMM Flyer.