Home     The Company The History of SocraTec R&D Our Goals and Visions Our Services Quality Management System Cooperation Partners Contact / Location Clinical Investigations Clinical Pharmacology Unit Phase-I Studies Phase-II/III Studies Absorption-Site Studies Proof-of-Concept Studies Special Populations Oncology Magnetic Marker Monitoring Procedure, Basic Principle Testing Unit Study Experience Applications Biopharmaceutics Drug Substance Dosage Form BSC Classification Product Improvement Brain Trust, Expertise Consulting Service Expert Reports Network of Experts Development Concepts Infocentre Lectures/Presentations Publications/Review Articles Seminars/Conferences Links   Optimization of clinically proven medicinal products Background Even medicinal products used successfully in therapeutic practice over decades may not be the optimum. New findings in pharmacology, deeper insights in physiology and a better understanding of the clinical circumstances may form an appropriate base for optimizing such products and thus improving the treatment options. Concepts Improvements of medicinal products should be oriented towards relevant clinical needs. If the existing products do not meet all therapeutic goals, then modifications should be taken into account. In such cases the following changes may be considered: Modified release/drug delivery: modifications should be based on pharmacokinetic considerations ("target profile"), e.g. retardation to improve safety and tolerability Modified gastro-intestinal transit: modifications may be advantageous in case of compounds which are not absorbed consistently from all parts of the GI tract Therapy "adjusted" dosing regimen: adjustments seem useful e.g. in cases of diurnal variation of symptoms or clinical effects Our offer The development of appropriate concepts, the design of proof-of-concept studies and the preparation of complex development plans are part of our core business. Together with Prof. Mutschler and Prof. Weitschies, we look forward to working with you.       © 2003-2013 SocraTec R&D GmbH deutsche Version Imprint