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Solubility: Poorly soluble compounds frequently imply significant bioavailability
problems, which require appropriate formulation design features.
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Absorption site: A number of drug substances are not going to be absorbed evenly throughout
the entire gastro-intestinal tract. For the development of extended release preparations,
in particular for once daily treatment,
absorption conditions have to be
known and should be taken into account consequently.
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Gastro-intestinal transit: The biopharmaceutical performance of medicinal products can be
significantly affected by the physiology of the gastro-intestinal tract. The knowledge of
relevant interactions, e.g. elucidated by means of gastro-intestinal
imaging studies, offers an appropriate basis
for the development of improved solid oral dosage forms.
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