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To understand unexpected pharmacokinetic phenomena:
The interpretation of unusual plasma concentration-time profiles of a drug, and these are
not uncommon (e.g. double peaks) is difficult and usually speculative. In many of these
cases application of the magnetic marker monitoring technique provides a better insight
and makes it possible to find an explanation for the effects. The key to success often
depends on knowing exactly how long a drug formulation remains in the stomach.
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Localization of drug release in the gastrointestinal tract:
Information on the location and kinetics of in-vivo drug release from a dosage form is
decisive for the development of products with modified release and those for topical
application to specific parts of the gastrointestinal tract. Investigations using magnetic
marker monitoring provide the means for optimising such drug formulations.
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In-vitro/in-vivo correlations:
The standard procedure for establishing such a correlation often stretches the limits of
interpretation, in most cases because of the lack of information on the performance of the
product in the gastrointestinal-tract. This gap can be closed using the magnetic marker
monitoring technique and thus, the reliability of conclusions reached may be greatly
improved.
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