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Location, mechanism and kinetics of drug absorption
Detailed knowledge of the location in the gastro-intestinal tract where compounds are predominantly
absorbed is essential for rational product development. Technology and formulation of oral dosage
forms are generally important factors affecting the rate and extent of absorption. This is especially
true in the case of modified release products.
The targeted administration of an investigational drug substance into the
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empty stomach,
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upper duodenum or
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jejunum
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and subsequent pharmacokinetic measurements in plasma can provide key information in this regard. For
this purpose a standardized intestinal tube technique has been established in our Clinical Pharmacology
Unit in Erfurt.
The successful designing and performing of such studies require specific know-how in the field as well
as wide-ranging experience. In this context several aspects are important, e.g. the composition of the
administered preparation, including the electrolytes, as well as the precise targeting of the region
for drug administration.
The comprehensive expertise of our specialists in this field, which is documented in the definition of
requirements and standard techniques, enables us to provide customers with the best scientific advice
and excellence in carrying out such projects.
Our skilled personnel together with well informed volunteers allow a straightforward and successful
performance of these sophisticated investigations and ensure high compliance, even in the case of
multiple drug administration periods.
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